Selective serotonin reuptake inhibitors (SSRIs and SNRIs) have lengthy been marketed because the magical resolution to despair and anxiousness, promising reduction in a handy little capsule. However behind the shiny pharmaceutical advertisements and physician endorsements lies a much more troubling actuality. These medication don’t simply alter your mind chemistry — they will hijack your feelings, disrupt your life, and result in penalties far worse than the circumstances they declare to deal with.
In truth, there’s a unclean secret of the SSRI antidepressants — they trigger psychotic violence which usually ends in suicide and typically in horrific murder (e.g., mass shootings). Remarkably, this aspect impact was found all through their scientific trials, lined up by the drug corporations, after which lined up by the FDA after the company obtained a deluge of complaints1 (39,000 within the first 9 years2) as soon as the primary SSRI, Prozac, hit the market.
Initially, the media would report on the prescriptions (SSRIs) mass shooters took. Nevertheless, a gag order went out, it turned unimaginable to know what drugs shooters have been on, and the subject turned taboo to debate. Happily, that not too long ago modified (e.g., after an article I wrote compiling the proof they trigger mass shootings went viral, Tucker Carlson did a 2022 phase on it and distinguished conservatives steadily started talking brazenly about SSRI mass shootings3).
In July 2022 @TuckerCarlson broke a serious taboo by discussing the hyperlink between antidepressants and mass shootings—an issue that didn’t exist till SSRIs entered the market.
Regardless of being written off as a “conspiracy idea” business research constantly confirmed that SSRIs trigger… pic.twitter.com/aSaPBndNzQ— A Midwestern Physician (@MidwesternDoc) January 7, 2025
Observe: I not too long ago realized by way of a CDC official that the CDC has been silently monitoring what mass shooters are on and located the SSRI hyperlink continues however has not disclosed it as a result of political earthquakes this admission would trigger.
The Toxicology Bell Curve
In toxicology, you’ll sometimes see extreme and excessive reactions happen a lot much less incessantly than average reactions:
Due to this, when a really regarding and unmistakable antagonistic response happens (e.g., the COVID-19 vaccines inflicting sudden deaths in younger wholesome athletes), that means you’re solely seeing the tip of the iceberg and much much less extreme accidents are additionally occurring far more incessantly.
For instance, one estimate4 discovered that of these vaccinated for COVID, 18% have been injured, 0.93% have been disabled, and 0.05% to 0.1% died, whereas one other survey5 discovered 41% of these vaccinated have been injured, with 7% being severely injured.
Within the case of the SSRIs, the psychotic violence they will create, sadly, can be simply the tip of a really massive iceberg, and there are a lot of much less extreme methods they warp your thoughts, physique, and feelings.
The Hidden Facet Results of SSRIs
Many datasets present the hurt SSRIs trigger drastically outweighs any advantages. For instance, in a survey of 1,829 sufferers6 on antidepressants in New Zealand:
62% reported sexual difficulties | 60% felt emotionally numb | 52% felt not like themselves |
39% cared much less about others | 47% had skilled agitation | 39% had skilled suicidal ideation |
In that survey, different much less widespread reported unintended effects (so as of reducing frequency) included: insomnia, nightmares, “fuzzy”/”zombie,” jaw grinding, sweating, blurred imaginative and prescient, constipation, disturbed/stressed sleep, anxiousness, coronary heart palpitations, problem considering, fatigue/exhaustion, unusual/vivid goals, stiff muscle tissue/joints, “mind zaps,” mania, extreme yawning, panic assaults, reminiscence loss, decreased motivation, night time sweats, and decreased urge for food.
This record matches what I’ve seen in lots of different datasets7 (though others like feeling agitated, shaky, or anxious, indigestion, abdomen aches, and diarrhea are additionally generally reported).
Observe: One other main concern with SSRIs (which is unlikely to be detected on a symptom-based survey) is that SSRIs incessantly trigger bipolar dysfunction.
Psychotic Violence — A Suppressed Reality
When Prozac was first dropped at market within the mid-Nineteen Eighties, the pharmaceutical business had not but satisfied the world that everybody was depressed and wanted an antidepressant. So, as a substitute (on condition that SSRIs work in an analogous method to a stimulant like Cocaine8) Prozac was initially marketed as a “mood-lifter.”
Likewise, in 1985 when the FDA’s security reviewer scrutinized Eli Lily’s Prozac software, they realized Lily had “failed” to report psychotic episodes of individuals on the drug and that Prozac’s antagonistic results resembled that of a stimulant drug.
In flip, the warnings on the labels for SSRIs,9 similar to anxiousness, agitation, panic assaults, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania, and mania, match the results generally noticed with stimulant avenue medication similar to cocaine and methamphetamine.
Observe: A big survey of discovered 44% stopped a psych med due to unintended effects, 1 / 4 of which have been as a result of SSRI agitation.10
In mild of this, and SSRI violence generally being blamed on a “pre-existing psychological sickness” I thus compiled quite a few research (together with ones business tried to bury) exhibiting the medication themselves trigger violence. For instance:
• A Cochrane evaluation11 assessed 150 research the place wholesome volunteers got SSRIs and located roughly one-third of them intentionally omitted discussing SSRI unintended effects, and about half of the research have been by no means made publicly obtainable (presumably to cover their regarding information).
In the end, 14 of the 150 research have been eligible for meta-analysis (since sufficient info existed in them for the researchers to know what really occurred), and in these 14 research, SSRIs have been discovered to double the chance of suicide.
• In 2000, David Healy revealed a examine12 he had carried out with 20 wholesome volunteers — all with no historical past of despair or different psychological sickness — and to his massive shock two (10%) of them turned suicidal once they obtained Zoloft. One among them was on her means out the door to kill herself in entrance of a practice or a automotive when a cellphone name saved her.
Each volunteers remained disturbed a number of months later and severely questioned the soundness of their personalities.
• Eli Lilly confirmed in 197813 that cats who had been pleasant for years started to growl and hiss on Prozac and have become distinctly unfriendly. As soon as Prozac was stopped, the cats returned to their common pleasant conduct in per week or two.
Observe: The FDA hypothesized that SSRIs might scale back violence in some however trigger a rise in violence in others.14 Likewise a evaluation of 84 animal research confirmed that decreased aggression upon therapy with SSRI was mostly noticed, however typically the animals as a substitute turned extra aggressive.15
Sexual Dysfunction
One of many unintended effects that I really feel finest illustrates the poor risk-reward ratio of SSRIs is sexual dysfunction — as not with the ability to have intercourse is kind of more likely to make somebody depressed (and in some circumstances suicidal16) — therefore usually utterly invalidating the justification for taking an SSRI to “really feel completely satisfied once more.”
For instance, a Spanish examine17,18 of 5 of 1,022 sufferers on essentially the most generally prescribed SSRIs discovered:
- The medication triggered sexual disturbances in 59% of them and 40% thought-about that dysfunction unacceptable
- 57% skilled decreased libido
- 57% skilled delayed orgasm or ejaculation
- 46% skilled no orgasm or ejaculation
- 31% skilled erectile dysfunction or decreased vaginal lubrication
Observe: Related outcomes have been obtained in different research,19 and I’ve met many women and men who continued to expertise sexual dysfunction lengthy after they stopped the SSRI (as this dysfunction is commonly everlasting).
What I discover essentially the most superb about SSRI sexual dysfunction is that whereas psychiatrists are likely to downplay or ignore it, they concurrently market SSRIs to deal with untimely ejaculation — which is yet one more instance of the drug business attempting to have its cake and eat it (particularly on condition that most of the SSRI producers additionally promote medication for erectile dysfunction).
Observe: One purpose this aspect impact is underneath acknowledged is that embarrassed sufferers usually gained’t report it until they’re particularly requested about it (e.g., within the Spanish examine, whereas 59% of SSRI customers reported sexual dysfunction, solely 20% did so with out prompting20 — one thing unlikely to be achieved in a drug trial geared toward getting a medicine to market).
Emotional Blunting — Shedding the Essence of Life
As soon as the SSRIs hit the market, I instantly seen that SSRIs typically dramatically altered the persona of those that took them. For instance, they usually destroyed the drive folks needed to make one thing of their life — and in some circumstances, I sadly watched that derailment proceed for many years.
Likewise, I started to listen to tales of individuals describing how their expertise of life was deadened, usually in a fashion not too totally different from how the medication “numb” your sexuality. A number of the widespread tales included:
• Not having emotional responses to issues you need to have responses to — For instance, I noticed quite a few circumstances of individuals being in unhealthy jobs or relationships, seeing a physician for assist with their despair, shortly being placed on Prozac, after which losing a decade of their life as a result of Prozac (or one other SSRI) eliminated their drive to depart that poisonous state of affairs. Likewise, I heard many individuals state that Prozac took away the enjoyment they felt in life.
• Shedding the depth and richness of life — This remark for example, does a superb job of illustrating that:
Observe: In psychiatry, this emotional anesthesia (not discovering issues as gratifying as one used to) is named “emotional blunting.” Relying on the examine (e.g., these talked about above) between 40% to 60% of those that take SSRIs expertise this aspect impact, and it’s typically rationalized as a obligatory trade-off for eradicating the emotional ache related to despair.
One of many biggest issues with our society is the assumption that the media has marketed to us that we must always by no means should really feel unfavourable feelings. In actuality, they’re a essential part of the human expertise and are incessantly obligatory for our development and figuring out the right path for our lives. Sadly, to market despair (and SSRIs) it was essential to pathologize regular sides of life and switch them into everlasting diseases requiring indefinite therapy.
Delivery Defects — A Hidden Consequence
As soon as a drug will get accepted, pharmaceutical corporations will at all times attempt to develop their marketplace for it (e.g., this is the reason after adults stopped wanting the preliminary COVID-19 vaccine, they pivoted to pushing it on kids — despite the fact that kids have an virtually 0% probability of dying from COVID-19).
With SSRIs, the business has likewise labored to push them on weak teams (e.g., foster kids, “struggling” college students, prisoners or parolees, pregnant moms, and the aged), and every group has suffered vital penalties from these practices — significantly since many are usually not allowed to say no the medication. This glorious skit by Peter Gøtzsche illustrates the absurdity of pushing them on pregnant ladies:
As a result of the SSRI’s have been shielded from scrutiny, they’re incessantly pushed on sufferers (typically towards their consent) when the medication dangers drastically outweigh their advantages. This skit for instance highlights the unconscionable SSRI recommendation pregnant ladies incessantly obtain: pic.twitter.com/X5zKC1Jzhv
— A Midwestern Physician (@MidwesternDoc) January 7, 2025
Pushing SSRIs on pregnant ladies is rationalized by the actual fact ladies incessantly get depressed throughout or after their pregnancies (which is commonly as a result of extreme copper ranges — one thing fairly simple to deal with naturally). Sadly, there are a number of the explanation why SSRIs are usually not secure throughout being pregnant. These embody:
• SSRIs improve the chance of untimely births,21 with the best threat (a doubling) occurring if an SSRI is taken in the course of the third trimester.
• SSRIs considerably improve the chance of septal defects22 (which regularly require coronary heart surgical procedure to restore). One examine of 500,000 infants in Denmark discovered moms taking a single SSRI whereas pregnant triggered the chance of a septal defect of their baby to go from 0.5% to 0.9% and taking two or extra elevated it to 2.1%. Moreover, whereas on common taking an SSRI doubled the chance of a delivery defect, the elevated threat ranged from 34% to 225%, relying on the SSRI.
• SSRIs considerably improve the chance of persistent pulmonary hypertension in a new child child. One examine of 1,173 infants discovered SSRIs elevated the chance of it by 6.1 instances,23 whereas one other discovered the chance elevated by 4.29 instances,24 whereas one other discovered it elevated by 2.5 instances.25
On condition that this situation impacts 1 to 2 out of 1,000 births and is commonly deadly, this “small” threat provides up fairly shortly (however nonetheless this was not sufficient for the FDA to rethink its advocacy of those medication for pregnant ladies26).
Observe: Different new child problems linked to SSRIs embody irritability, tremor, hypertonia, and problem sleeping or breastfeeding.
Sadly, after delivery SSRIs proceed to have an effect on the event of a kid. For instance, the bundle insert for Prozac states that after solely 19 weeks of therapy, kids misplaced 1.1 cm (0.43 inches) and 1.1 kg in weight (2.43 lbs.) in comparison with kids handled with placebo.27
The Function of Advertising in SSRI Reputation
A lot in the identical means, the pharmaceutical business spends exorbitant quantities of cash dishonestly advertising medication, it’s going to incessantly concoct elaborate methods to make a ineffective (or worse) drug seem like price promoting to all of America (for my part finest encapsulated by the idiom “Placing Lipstick on a Pig”28).
Since “despair” is so subjective, it’s even simpler to sport this analysis. Consequently, when the “profitable” research of antidepressants are fastidiously examined, like many different prescribed drugs (e.g., the COVID and HPV vaccines), the advantages are comparatively inconsequential whereas the far larger dangers are hid with elaborate reclassifications.
Observe: Antidepressants do work for a metabolic subset of sufferers (whose metabolic dysfunction can be handled naturally). Sadly, physicians are by no means skilled to display screen for these sufferers, as that screening would eradicate nearly all of potential SSRI clients.
Happily, there are a number of metrics you can’t cowl up. One of the crucial well-known ones is total mortality (how many individuals in complete on vs. off the drug died) since you may’t reclassify dying. One other is what number of sufferers voluntarily selected to cease taking a medicine:
• A evaluation of 29 revealed and 11 unpublished scientific trials containing 3,704 sufferers who obtained Paxil and a pair of,687 who obtained a placebo, discovered an equal proportion of sufferers in each teams left their examine early (suggesting Paxil’s advantages didn’t outweigh its aspect impact), and that in comparison with placebo, 77% extra stopped the drug due to unintended effects and 155% extra stopped as a result of they skilled suicidal tendencies.29
• A examine of seven,525 sufferers, discovered that 56% of them selected to cease taking an SSRI inside 4 months of being prescribed it.30
• A world survey of three,516 folks from 14 affected person advocacy teams discovered that 44% had completely stopped taking a psychiatric drug as a result of its unintended effects.31
• A survey of 500 sufferers discovered 81.5% have been not sure if their antidepressants have been obligatory.32
Put otherwise, if most sufferers really feel worse on a medicine they’re taking to “really feel good” than they do with out it, meaning the trials proclaiming the drugs made sufferers really feel higher have been fraudulent.
In flip, hundreds of remarkably comparable tales might be discovered on-line.33 Sufferers expertise a variety of beforehand unimaginable unintended effects that shake the very basis of their world, assume one thing should be improper with them (therefore going by way of a interval of disbelief), discover no help or understanding throughout the medical area — after which ultimately understand they’d been trusting their docs to have a certain quantity of information they don’t even have.
“And you realize, that is heartbreaking. I went by way of this, and I felt that the world had fallen out from beneath me. There wasn’t any medical security internet. So the sociological phenomenon exists, and has not but filtered into drugs. Drugs has its personal methods of gathering info, and in psychiatry, for some purpose, they hold asking one another what the reality is as a substitute of asking their sufferers. The affected person voice will not be very nicely acknowledged in psychiatry in any respect.”34
Observe: This SSRI expertise mirrors many different pharmaceutical accidents (e.g., I’ve heard virtually similar tales from numerous people injured by the COVID-19 vaccines).
Most significantly, many sufferers report that their prescribers don’t warn them about most of the SSRI unintended effects. Briefly, many individuals I do know haven’t solely needlessly been severely impacted by these medication but in addition gaslighted35 by the docs they sought care from.
Conclusion
Over time, I’ve requested numerous holistic docs what they contemplate to be the 5 most harmful, extensively prescription drugs within the market, and with out exception, SSRIs at all times make that record. On this article, I’ve tried for example among the most frequent harms of those medication, however sadly it solely touches on the floor.
For instance, due to how they’re dosed, SSRIs are extremely addictive, and as soon as they’re partially decreased, a wide range of extreme signs can onset (e.g., dose adjustments generally proceeds SSRI suicides and homicides,36 which is why you need to by no means abruptly cease taking them).
Tragically, docs are usually not skilled to acknowledge these withdrawals (docs sometimes as a substitute interpret them as a pre-existing sickness not being counteracted by the SSRI and proceed to push the medication), and only a few know learn how to safely taper sufferers off SSRIs.
Happily, with the MAHA motion, that is starting to alter. For instance, contemplate what RFK Jr. acknowledged37 when he shared this text:
As such, for the primary time in my life, I’m sincerely hopeful this practically 40 12 months tragedy finally will finish.38 As such, it’s now crucial every of us do all we are able to to reveal the Forgotten Sides of Drugs so we are able to create public stress to finish these pharmaceutical atrocities and produce again the unimaginable pure therapies that have been faraway from the market to guard these grotesque pharmaceutical monopolies.
Writer’s word: That is an abridged model of an extended article which discusses the above factors in far more element and discusses learn how to safely withdraw from SSRIs. That article and its further references might be learn right here. Moreover, a companion article in regards to the despair business and efficient pure therapies for despair might be learn right here.
A Observe from Dr. Mercola In regards to the Writer
A Midwestern Physician (AMD) is a board-certified doctor from the Midwest and a longtime reader of Mercola.com. I recognize AMD’s distinctive perception on a variety of subjects and am grateful to share it. I additionally respect AMD’s need to stay nameless since AMD continues to be on the entrance traces treating sufferers. To search out extra of AMD’s work, be sure you take a look at The Forgotten Facet of Drugs on Substack.
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